The improved Gorilla genome using advanced reading long term DNA techniques

Genome assembly is evolving quickly due to the reading long DNA techniques. Scientists from the University of Washington, the McDonnell Genome Institute, among other organizations reached a new step on genome assembly, filling almost all gaps on it. Susie, a female Western lowland gorilla, was used as the reference sample.

The first full gorilla genome was sequenced in 2012. However, the old genome contains more than 400,000 sequence gaps, and previous genome assembly methods resulted in some inaccurate genetic structuring.  This new assembly,  named Susie3, has closed 94% of the 433,861 sequence gaps that were in the previous research, gorGor3 genome.

The study was published in the journal Science, and concludes that "The genome assembly that results from using the long-read data provides a more complete picture of gene content, structural variation, and repeat biology, improving population genetic and evolutionary inferences. Long-read sequencing technology now makes it practical for individual laboratories to generate high-quality reference genomes for complex mammalian genomes".

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